It will mark the fifth time she has taken the Grammy stage. The seven-time Grammy Award winner last performed on the show just a year ago, with Macklemore & Ryan Lewis.
The 57th Grammy Awards comes two days before Madonna's new single, "Living For Love," will officially begin its promotion to U.S. radio. It's the lead track from the Rebel Heart album, which will be released on March 10 through Interscope Records.
Watch the last performance that made history